EVALUATION OF MOLECULAR MONITORING AND RESPONSE MILESTONE OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA TO TYROSINE KINASE INHIBITORS IN MIDDLE EUPHRATES OF IRAQ

Background: In the last decade, tremendous changes occurred in the treatment and follow-up of the patients with chronic myeloid leukemia (CML), with continuous update in the close molecular monitoring of treatment for the presence of minimal residual disease.Objectives: The objective of this study was to evaluate read more the molecular monitoring

The antiviral endoribonuclease, RNase L, is activated by the mammalian innate immune response to destroy host and viral RNA to ultimately reduce viral gene expression.Herein, we show that RNase L and RNase L-mediated mRNA decay are primarily localized to the cytoplasm.Consequently, RNA-binding proteins (RBPs) translocate from the cytoplasm to flexc

Large Language Models (LLMs) have found increasing application in tasks requiring multi-step reasoning, yet challenges such as hallucinations and inconsistencies in the generated responses persist.This study presents an innovative methodology to enhance the reasoning capabilities of LLMs by brokering and integrating multiple expert LLMs within a re

Compliant mechanisms based on flexure hinges are widely used in precision engineering applications.Among those are devices such as precision balances and mass comparators with achievable resolutions and uncertainties in the nano-newton range.The exact knowledge of the mechanical properties of notch hinges and their modeling is essential for the des

The endosomal sorting complex required for transport (ESCRT) is an essential molecular machinery in eukaryotic cells that facilitates the invagination of endosomal membranes, leading to the formation of multivesicular flexcon reverse osmosis water storage tank bodies (MVBs).It participates in various cellular processes, including lipid bilayer remo